Effect of Acute L-Arginine Supplementation on Cardiac and Muscle Cell Damage Indices after Exhaustive Exercise Training in Young Karate Players

Document Type : Research Paper



Introduction: The aim of this study is to investigate the effect of short-term L-arginine supplementation on lactate dehydrogenase (LDH), creatine kinase (CK) and troponin T (Tnt) enzymes levels after exhaustive exercise in young karate players.
Materials and Methods: In semi-experimental study, 18 young karate players randomly assigned in two supplement and placebo groups. Participants in supplement group consumed 3grams daily of L-arginine capsules for seven days, while the placebo group received the same amount of placebo. All subjects performed an exhaustive aerobic exercise after seven days supplementation. Venous blood samples were collected at four stages; 1: pre supplementation, 2: After the end of the supplementation period and pre exercise, 3: Immediately post exercise and 4: 24 hours after exercise. Data was analyzed by repeated measure ANOVA and Bonferroni post-hoc test at α ≤ 0.05.
Results: The results of the study indicated that the increase of CK, was significantly higher (p<0/05) at the immediately and 24 hours after exercise in the placebo group as compared to the L-arginine group. However, the LDH and Tnt levels significantly increases in both placebo and supplement group at the immediately and 24 hours after exhaustive exercise (p<0/05).
Conclusion: In general, it can be concluded that short-term L-arginine supplementation can ameliorate the muscle cell damage induced to exhaustive exercise by prevention of the CK increase in young athletes.


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