The Effect of 16 Weeks of Low Calorie Diet on Irisin Serum Levels and Insulin Resistance Index in Obese Sedentary Women

Document Type : Research Paper



Introduction: Irisin is a new adipokine that is released from membrane protein FNDC5 and has positive effects on metabolism. The aim of this study was to survey the effects of caloric restriction on serum irisin levels and insulin resistance index in obese sedentary women.
Materials and Methods: Twenty women (Mean± SD: 41.40±4.53 years; 76.69±6.14 Kg) who referred to home health of west of Tehran were divided into two groups; caloric restriction group (n=10) and control group (n=10). The calorie restriction group, in the intervention period, received 25% less than the estimated daily energy requirement. Serum irisin, glucose, insulin levels and insulin resistance using HOMA-IR were measured before and after 16 weeks.
Results: Weight, BMI (body mass index), WHR (waist to hip ratio), serum irisin, fasting glucose, fasting insulin and HOMA-IR were decreased significantly in the caloric restriction group. Significant correlation were observed between changes of serum irisin levels with changes of body weight, WHR, HOMA-IR, fasting glucose and fasting insulin levels (p<0.05).
Conclusion: There is a significant correlation between serum irisin levels with BMI, WHR and HOMA-IR. 16 weeks of caloric restriction is effective in reduction of serum irisin levels and insulin resistance in obese sedentary women.


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